Eurycoma Longifolia is famously known for its various pharmacological activities, consisting of various types of important bioactive compounds, mainly in Eurycomanone, the highest concentrated quassinoid. The presence of quassinoid together with other phytochemicals found in the plant contributes to remarkably therapeutic effects as following;
Eurycoma Longifolia is famously renowned for its aphrodisiac effect, which is due to its ability to stimulate the production or action of androgen hormones, especially testosterone from its major compound Eurycomanone. The root which is the most valuable component, is reported to possess wide range of phytochemicals including quassinoids (eurycomanone), canthine-6-one alkaloids, squalene derivatives and by-phenylneolignans which are the reasons behind its testosterone increasing effect. Hence, it can be used as an alternative for testosterone replacement therapy in the treatment of androgen deficiency, one of the major factors of sexual dysfunction, associating with premature ejaculation, erectile dysfunction, and reduced libido. Regarding to an increased production of testosterone, the plant is also believed to be efficient for sexual potency including;
- Energy and vitality
- Erectile dysfunction
- Premature Ejaculation
Among local people, Eurycoma Longifolia is typically consumed as herbal drinks to for increased high blood pressure, fatigue and sports performance.
Prevention of Male Osteoporosis
Recently, the use of Eurycoma Longifolia has gone beyond traditional medicine. With its testosterone enhancing eﬀects, the plant is also suggested as a complementary medicine for androgen-deficient osteoporosis. As androgen playing an important role in regulating bone health, low testosterone level can bring about bone loss and osteoporosis. However, with the bioactive complex polypeptides, called eurypeptides and its proandrogen properties, it can exert and enhance eﬀects on the biosynthesis of various androgens by stimulating osteoblast pro-liferation and diﬀerentiation, resulting in increased bone formation rate. Other than its proandrogenic properties, Eurycoma Longifolia also contains high level of nitric oxide (NO) and antioxidant activity from alkaloids and triterpenes that have eﬀects on bone by acting as a mediator to promote bone formation and suppress bone resorption. Eurycoma Longifolia is therefore, suggested to be potential as testosterone replacement for androgen deficient osteoporosis.
Quassinoids along with canthine alkaloids isolated from roots of E. longifolia are known to possess potent antimalarial activity against various strains of Plasmodium falciparum parasites. It is claimed that a combination of standard antimalarial agent and antimalarial herbal extract is beneficial in combating the infection caused by malaria parasite.
Over the years, pharmacological evaluations of this plant showed that this promising herbal medicine has antibacterial, antitumor, antipyretic, anti-inflammatory and antioxidant properties. In folk medicine, decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever.
Eurycoma Longifolia is also used to treat bleeding gums, oedema, jaundice, cachexia, rheumatism, flatulence, indigestion, wounds, syphilis, lumbago, and to relieve gastric ulcer.
Testosterone is the most important representative of the male sex hormones collectively known as androgens produced by the gonads. Its secretion stimulates the differentiation of the male reproductive tract in the embryo, the decent of the testes in to the scrotum, the further development of the reproductive tract and penis during puberty and maturation of the sperm. It is also responsible for the development of male secondary sex characteristics such as moustache, beard, enlargement of the larynx (deep voice) and increase production of the sebaceous glands, all of which are associated with masculine features. Testosterone also plays a role in the development and maintenance of male libido (sexual desire) and sexual behavior. Anti-Fever-Effects, Anti-Malarial-Effect, Anti-oxidant-Properties.
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